Bioassay of 4,4"-methylenebis-(n,n-dimethyl)benzenamine for possible carcinogenicity
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Bioassay of 4,4"-methylenebis-(n,n-dimethyl)benzenamine for possible carcinogenicity

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Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health in Bethesda, Md .
Written in English


  • Carcinogens.,
  • Benzidine dyes -- Toxicology.,
  • Dyes and dyeing -- Toxicology.

Book details:

Edition Notes

StatementCarcinogenesis Testing Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health.
SeriesCarcinogenesis technical report series ; no. 186, DHEW publication ; no. (NIH) 79-1742, DHEW publication -- no. (NIH) 79-1742.
ContributionsNational Institutes of Health (U.S.).
The Physical Object
Paginationxxi, 58 p. :
Number of Pages58
ID Numbers
Open LibraryOL18014812M

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4,4′-methylenebis(N,N-dimethyl)benzenamine. Properties 4,4′-Methylenebis(N,N-dimethyl)benzenamine is a bicyclic aro-matic amine that exists at room temperature as yellowish glisten-ing leaflets or plates or as tan crystals with a faint odor (NCI , Akron , HSDB ). Commonly referred to as Michler’s base,File Size: KB. Search results for 4,4'-methylenebis at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare. IUPAC Standard InChIKey: YBRVSVVVWCFQMG-UHFFFAOYSA-N CAS Registry Number: Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript. Other names: Aniline, 4,4'-methylenedi-; p,p'-Diaminodiphenylmethane; p,p'-Methylenedianiline; Bis(p-aminophenyl)methane; Bis(4 . Sufficient. NCI (a) conducted a bioassay of 4,4'-methylenebis(N,N- dimethylaniline) in rats and mice. Groups of 50 male and 50 female F rats were given and ppm of the.

4,4'-Methylenebis(2-chloroaniline) (also known as MOCA, MBOCA, and bisamine) is a substance used as a curing agent in polyurethane production. MOCA is an aromatic amine which is structurally similar to benzidine, a known human bladder has been shown to cause hepatomas in mice and rats, lung and mammary carcinomas in rats and bladder cancer in : faint, amine-like. Temperature (K) A B C Reference Comment; - Zalikin and Strepikheev, Coefficents calculated by NIST from author's data. Unfortunately, this book can't be printed from the OpenBook. Visit to get more information about this book, to buy it in print, or to download it as a free PDF. The DuPont Chambers Works in Deepwater, N.J., was a major producer of two carcinogens (beta-naphthylamine and benzidine) and two suspected bladder carcinogens (ortho-toluidine and 4,4'-methylenebis [2-chloroaniline]).

Hazard classification and labelling. The ‘Hazard classification and labelling’ section shows the hazards of a substance through a standardised system of statements and pictograms, as has been established under CLP (Classification Labelling and Packaging) Regulation. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in. The chemical properties of 4,4'- Methylenebis (2-Chloroaniline) indicate that about 43% will enter the water, 28% aquatic sediments, and 30% terrestrial soil. The concentration of 4,4'-Methylenebis (2-Chloroaniline) found in fish tissues is expected to be somewhat higher than the average concentration of 4,4'-Methylenebis (2-Chloroaniline) in. 2-Chlorobenzenamine. Molecular Weight: O-chloroaniline is a clear amber liquid with an amine odor. Occurs in both alpha and beta forms. (NTP, ) from CAMEO Chemicals. Expand this section. 2 Names and Identifiers. Expand this section. 3 Chemical and Physical Properties. Expand this section. 4 Spectral Information. Expand this section. 4,4'-Methylenebis(phenyl isocyanate) acts as a monomer in the production of polyurethane. The rigid polyurethane foams are good thermal insulators, which find applications in all freezers and refrigerators, as well as in buildings. It is also used as an industrial strength adhesive, which is available to end consumers as various high-strength.